US demand for diabetes monitoring products and therapies is expected to grow 9.5 percent annually through 2008. Gains will be driven by more diabetes patients and more aggressive treatments. Best prospects include electrochemical blood glucose test strips, prefilled disposable insulin pen injectors, and TZD and peptide agonist oral anti-diabetic agents.

This study analyzes the $11 billion US diabetes monitoring product and therapy industry. It presents historical (1993, 1998, 2003) demand data and forecasts to 2008 and 2013 by product (e.g., blood glucose tests and monitors, diabetes diagnostics, insulin injectors, insulin pumps and accessories, insulin dosages, oral anti-diabetic agents); and by market.

The study also considers market environment factors, details industry structure, evaluates company market share and profiles 24 major players including Eli Lilly, GlaxoSmithKline, Bristol-Myers Squibb, Johnson & Johnson, Sanofi-Aventis, Roche, Bayer, Abbott Laboratories, Novo Nordisk, and Medtronic MiniMed.

                           TABLE OF CONTENTS
                                    
  
  SECTION                                                          PAGE
  
         INTRODUCTION                                                 x
         
   I.    EXECUTIVE SUMMARY                                            1
  
  II.    MARKET ENVIRONMENT                                           4
         General                                                      4
         Economic Factors                                             5
           Recent Economic Trends                                     6
           Long-Term Economic Projections                             7
         Demographic Patterns                                         9
         Trends in Health Care                                       11
           Health Insurance                                          12
           National Health Expenditures                              15
           Medical Providers                                         18
           Patient Activity                                          21
         Diabetes Overview                                           23
           Incidence                                                 24
              Type 1 Diabetes                                        24
              Type 2 Diabetes                                        25
              Gestational Diabetes                                   25
           Treatment Costs                                           27
           World Diabetes Conditions                                 28
  
 III.    TECHNOLOGY OVERVIEW                                         30
         General                                                     30
         Biosensors                                                  31
         Recombinant DNA                                             33
         Stem Cell Research                                          33
         Insulin Dosage Formulations                                 35
         Other Technologies                                          36
           Chiral Chemistry                                          37
           Combinatorial Chemistry                                   38
           Monoclonal Antibodies                                     39
           Nanotechnology                                            40
  
  IV.    PRODUCT OVERVIEW                                            41
         General                                                     41
         Market Trends 1993-2003                                     43
         International Markets                                       45
           US Trade                                                  46
           World Market Outlook                                      48
  
   V.    BLOOD GLUCOSE MONITORING & DIABETES DIAGNOSTIC PRODUCTS     51
         General                                                     51
         Blood Glucose Monitoring Products                           53
           Blood Glucose Test Strips                                 55
              Technologies                                           56
              Producers                                              59
              Electrochemical Test Strips                            59
              Photometer Reflectance Test Strips                     62
           Blood Glucose Monitors                                    63
              Monitor Features & Capabilities                        64
              Point-In-Time Self-Testing Monitors                    67
              Professional Blood Glucose Monitoring Systems          74
              Continuous Self-Testing Monitors                       78
              Blood Glucose Monitors in Development                  81
           Blood Glucose Testing Supplies                            85
              Lancets                                                86
              Lancing Devices                                        88
              Biosensors                                             91
         Diabetes Diagnostic Products                                94
           Hemoglobin A1c Testing Products                           95
           Blood Glucose Reagents & Test Kits                        98
           Microalbumin Testing Products                            100
           Ketone Testing Products                                  102
           Other Diabetes Diagnostic Products                       104
  
  VI.    INSULIN DELIVERY SYSTEMS                                   107
         General                                                    107
         Insulin Injector Systems                                   109
           Pen Injectors                                            110
              Disposable Pen Injectors                              111
              Reusable Pen Injectors                                114
           Syringe & Needle Sets                                    117
           Needleless Jet Injectors                                 119
           Other Insulin Injection Supplies                         121
              Infectious Waste Disposal Supplies                    122
              Injection Aids                                        124
         Insulin Pumps & Accessories                                127
           External Pumps                                           128
              Pump Advantages                                       130
              Pump Disadvantages                                    130
              Producers & Products                                  130
           Implantable Pumps                                        132
           Pump Accessories                                         133
         Insulin Dosage Formulations                                135
           Types of Insulin                                         136
           Insulin Producers & Products                             138
           Insulin Vials                                            140
           Insulin Cartridges                                       141
           Inhalation Insulin                                       143
           Oral Insulin                                             146
           Transdermal Insulin                                      149
           Stem Cell Therapies                                      150
  
  VII.   ORAL ANTI-DIABETIC AGENTS                                  152
         General                                                    152
         Thiazolidinediones (TZDs)                                  154
           Indications & Actions                                    155
           Products & Producers                                     156
              Troglitazone                                          157
              Pioglitazone HCl & Rosiglitazone Maleate              157
         Biguanides                                                 160
           Indications & Actions                                    161
           Products & Producers                                     164
         Sulfonylureas                                              165
           Indications & Actions                                    166
           Products & Producers                                     168
         Meglitinides                                               169
           Indications & Actions                                    169
           Products & Producers                                     170
         Enzyme Inhibitors                                          171
           Indications & Actions                                    172
           Products & Producers                                     173
         Peptide Agonists                                           173
           GLP-1 Agonists                                           174
           LAF237                                                   176
           MK0431                                                   177
           Other Peptide Agonists                                   177
         Non-TZD Peroxisome Proliferator-Activated Receptors        178
         Other Oral Anti-Diabetic Agents                            180
  
 VIII.   MARKETS                                                    185
         General                                                    185
         Home Health Care Market                                    188
         Primary Health Care Market                                 190
         Other Markets                                              192
  
  IX.    INDUSTRY STRUCTURE                                         194
         General                                                    194
         Market Share                                               195
         Competitive Strategies                                     197
         Mergers & Acquisitions                                     199
         Licensing & Related Agreements                             200
         Regulatory Considerations                                  207
         Research & Development                                     210
         Marketing & Distribution                                   211
         Manufacturing                                              213
         Company Profiles                                           215
           Abbott Laboratories                                      216
           Alkermes Incorporated                                    220
           Aradigm Corporation                                      223
           Aventis SA, see Sanofi-Aventis                              
           Bayer AG                                                 225
           Becton, Dickinson and Company                            228
           Bristol-Myers Squibb Company                             231
           Cygnus Incorporated                                      234
           Disetronic Group, see Roche Holding Limited                 
           Emisphere Technologies Incorporated                      235
           GlaxoSmithKline plc                                      237
           IVAX Corporation                                         239
           Johnson & Johnson                                        240
           Kos Pharmaceuticals Incorporated                         243
           LifeScan Incorporated, see Johnson & Johnson                
           Lilly (Eli) and Company                                  245
           MannKind Corporation                                     250
           Medtronic Incorporated                                   251
           Merck & Company Incorporated                             255
           Novartis International AG                                257
           Novo Nordisk A/S                                         261
           OSI Pharmaceuticals Incorporated                         267
           Pfizer Incorporated                                      269
           Prosidion Limited, see OSI Pharmaceuticals                  
           Roche Holding Limited                                    271
           Sandoz Generics, see Novartis International AG              
           Sanofi-Aventis                                           276
           Takeda Pharmaceutical Company Limited                    280
           Terumo Corporation                                       282
           TheraSense Incorporated, see Abbott Laboratories            
  
    

                             LIST OF TABLES
                                   
    TABLE NUMBER                                                   PAGE
  
         SECTION I -- EXECUTIVE SUMMARY
         Summary Table                                                3
  
         SECTION II -- MARKET ENVIRONMENT
    1    Macroeconomic Indicators                                     5
    2    Population & Age Distribution                               11
    3    National Health Expenditures by Type                        18
    4    Medical Providers                                           21
    5    Patient Activity                                            23
    6    Diabetes Conditions                                         26
    7    Diabetes Expenditures                                       28
    8    World Diabetes Conditions                                   29
  
         SECTION IV -- PRODUCT OVERVIEW
    1    Diabetes Monitoring Products & Therapies Demand
           by Product Group                                          42
    2    Diabetes Monitoring Products & Therapies - Demand
           Patterns, 1993-2003                                       45
    3    US Trade in Diabetes Monitoring Products & Therapies        47
    4    World Diabetes Monitoring Products & Therapies Demand       50
  
  
         SECTION V -- BLOOD GLUCOSE MONITORING
           & DIABETES DIAGNOSTIC PRODUCTS
    1    Blood Glucose Monitoring & Diabetes Diagnostic
           Products Demand                                           52
    2    Blood Glucose Monitoring Products Demand by Type            55
    3    Blood Glucose Test Strips Demand by Type                    56
    4    Blood Glucose Test Strips - Selected Characteristics        58
    5    Electrochemical (EC) Blood Glucose Test Strips Demand       61
    6    Photometer Reflectance (PR) Test Strips Demand              63
    7    Blood Glucose Monitors Demand by Type                       64
    8    Blood Glucose Monitors - Selected Characteristics           67
    9    Point-In-Time Self-Testing Blood Glucose Monitors Demand    68
   10    Professional Use Blood Glucose Monitors Demand              75
   11    Continuous Blood Glucose Monitors Demand                    80
   12    Blood Glucose Testing Supplies Demand by Type               85
   13    Lancets Demand                                              88
   14    Lancing Devices Demand                                      91
   15    Biosensors Demand                                           94
   16    Diabetes Diagnostic Products Demand by Type                 95
   17    Hemoglobin A1c Testing Products Demand                      98
   18    Blood Glucose Reagents & Test Kits Demand                  100
   19    Microalbumin Testing Products Demand                       102
   20    Ketone Testing Products Demand                             104
   21    Other Diabetes Diagnostic Products Demand                  106
  
         SECTION VI -- INSULIN DELIVERY SYSTEMS
    1    Insulin Delivery Systems Demand by Type                    108
    2    Insulin Injector Systems Demand                            110
    3    Insulin Pen Injector Demand                                111
    4    Disposable Insulin Pen Injector Demand                     113
    5    Reusable Insulin Pen Injector Demand                       116
    6    Insulin Syringe & Needle Set Demand                        118
    7    Needleless Insulin Jet Injector Demand                     121
    8    Other Insulin Injector Supply Demand                       122
    9    Insulin Pump & Accessory Demand                            128
   10    External Insulin Pump Demand                               129
   11    Implantable Insulin Pump Demand                            133
   12    Insulin Pump Accessory Demand                              135
   13    Insulin Demand by Dosage Formulation                       136
   14    Insulin Vial Demand                                        141
   15    Insulin Cartridge Demand                                   142
  
         SECTION VII -- ORAL ANTI-DIABETIC AGENTS
    1    Oral Anti-Diabetic Agents Demand                           153
    2    Thiazolidinediones (TZDs) Demand                           155
    3    Biguanides Demand                                          161
    4    Sulfonylureas Demand                                       166
    5    Meglitinides Demand                                        169
    6    Enzyme Inhibitors Demand                                   171
    7    Peptide Agonist Demand                                     174
    8    Non-TZD PPARs Demand                                       180
    9    Other Oral Anti-Diabetic Agents Demand                     184
  
         SECTION VIII -- MARKETS
    1    Diabetes Monitoring Products & Therapies
           Demand by Market                                         187
    2    Home Health Care Market -- Diabetes Monitoring Products
           & Therapies                                              190
    3    Primary Health Care Market -- Diabetes Monitoring Products
           & Therapies                                              192
    4    Other Markets -- Diabetes Monitoring Products & Therapies  193
  
         SECTION IX -- INDUSTRY STRUCTURE
    1    Diabetes Monitoring Products & Therapies Sales
           by Company, 2003                                         196
    2    Selected Acquisitions & Divestitures                       200
    3    Selected Cooperative Agreements                            202
  
  
    

                            LIST OF CHARTS
                                   
    CHART NUMBER                                                   PAGE
  
         SECTION IV -- PRODUCT OVERVIEW
    1    Diabetes Monitoring Products & Therapies Demand
           by Product Group, 2003                                    43
  
         SECTION V -- BLOOD GLUCOSE MONITORING
           & DIABETES DIAGNOSTIC PRODUCTS
    1    Blood Glucose Monitoring & Diabetes Diagnostic Products
           Demand by Type, 2003                                      53
  
         SECTION VI -- INSULIN DELIVERY SYSTEMS
    1    Insulin Delivery Systems Demand by Type, 2003              109
  
         SECTION VII -- ORAL ANTI-DIABETIC AGENTS
    1    Oral Anti-Diabetic Agents Demand by Type, 2003             154
  
         SECTION VIII -- MARKETS
    1    Diabetes Monitoring Products & Therapies Demand
           by Market, 2003                                          187
  
         SECTION IX -- INDUSTRY STRUCTURE
    1    Diabetes Monitoring Products & Therapies Market 
           Share, 2003                                              197