US demand for enzymes will rise 4.8 percent annually to 2014. Gains will be driven by continued expansion of higher-value specialty enzymes in pharmaceuticals, diagnostics, research and biotechnology, and biocatalysts. In the biofuels segment, growth will moderate as the industry transitions to cellulases for producing biomass ethanol.

This study analyzes the $2.2 billion US enzymes industry. It presents historical demand data for the years 1999, 2004 and 2009, and forecasts for 2014 and 2019 by market (e.g., biofuels, food and beverage processing, research and biotechnology, cleaning products, diagnostics, animal feed) and product (e.g., carbohydrases, proteases, polymerases, nucleases, lipases).

The study also considers market environment factors, details industry structure, evaluates company market share and profiles 34 industry competitors, including Roche, Allergan and Genzyme.

				    TABLE OF CONTENTS

     SECTION									    PAGE

		Introduction							      XI

	I.	Executive Summary						       1

	II.	Market Environment						       4
		General								       4
		Demographic Trends						       5
		Macroeconomic Outlook						       8
		   Consumer Spending						      12
		   Manufacturing Trends						      15
		Food & Beverage Industry Outlook				      18
		Agricultural Outlook						      21
		   Crop Production						      24
		   Livestock & Poultry						      26
		National Health Expenditures					      27
		Petroleum & Refining Industry Outlook				      30
		Historical Market Trends					      33
		Pricing & Product Mix						      37
		Environmental & Regulatory Considerations			      39
		Intellectual Property Considerations				      42
		International Activity						      43
		Foreign Trade & US Production					      45
		   Imports							      46
		   Exports							      48

	III.	Technology							      51
		General								      51
		Enzyme Production Overview					      52
		Recombinant DNA Technology					      54
		Directed Evolution & Gene Shuffling				      55
		Protein Engineering Technology					      57
		Molecular Screening & Bioinformatics				      57
		Enzyme Immobilization						      59
		Extremophilic Enzymes						      60
		Enzyme Factories						      61

	IV.	Markets								      64
		General								      64
		Pharmaceuticals							      67
		   Pharmaceutical Industry Outlook				      68
		   Enzyme Demand						      70
		      Enzyme Replacement Therapy				      73
		      Neuromodulator						      77
			Cosmetic						      79
			Noncosmetic						      80
		      Digestive							      81
			Pancreatic Enzymes					      83
			Other Digestive Enzymes				              85
		      Cardiovascular Thrombolytic				      87
		      Other Pharmaceutical					      90
			Pulmonary						      91
			All Other						      92
		Biofuels							      95
		   Biofuel Industry Outlook					      96
		   Enzyme Demand						      99
		      Starch Enzymes						     101
		      Cellulosic & Other Biofuel Enzymes			     104
		Food & Beverage Processing					     106
		   Sweeteners							     109
		      Corn Sweetener Industry Outlook				     110
		      Enzyme Demand						     111
		   Dairy Products						     114
		      Dairy Industry Outlook					     115
		      Enzyme Demand						     117
 	              Cheese Production					             119
		      Other Dairy Products					     122
		   Bakery Products						     124
		      Baked Goods Industry Outlook				     125
		      Enzyme Demand						     126
		   Beverage Processing						     130
		      Beverage Industry Outlook					     131
		      Enzyme Demand						     133
			Wine & Fruit Juice Production				     135
			Beer, Distilled Spirits & Other Beverages		     137
		   Other Food & Beverage Applications				     139
		Research & Biotechnology					     142
		   Research & Biotechnology Industry Outlook			     143
		   Enzyme Demand						     145
		      DNA Amplification & Sequencing				     147
		      Other Research Enzyme Applications			     150
		Cleaning Products						     152
		   Cleaning Product Industry Outlook				     153
		   Enzyme Demand						     155
		      Laundry Detergents					     157
		      Dishwashing Detergents & Other Cleaners			     160
		Diagnostics							     162
		   Diagnostic Industry Outlook					     163
		   Enzyme Demand						     165
		Animal Feed							     169
		   Animal Feed Industry Outlook					     170
		   Enzyme Demand						     174
		      Non-Starch Polysaccharides				     177
		      Phytate & Other						     178
		Other Enzyme Markets						     181
		   Biocatalysts							     182
		   Cosmetics & Toiletries					     186
		   Textiles & Leather						     189
		      Textiles							     191
		      Leather							     195
		   Pulp & Paper							     196
		   All Other							     200
		      Oilfield Recovery & Production				     201
		      Water Treatment						     202
		      Odor Control & Decontamination				     202
		      Waste Treatment						     203
		      Rubber							     204
		      Developing Applications					     204

	V.	Products							     206
		General								     206
		Carbohydrases							     209
		   Alpha Amylases						     213
		   Glucoamylases						     217
		   Recombinant Human Glycosidases				     219
		   Cellulases							     222
		   Glucose Isomerases						     225
		   Lactases							     226
		   Pectinases							     228
		   Other Carbohydrases						     231
		Proteases							     233
		   Microbial Proteases						     235
		   Fibrinolytic Proteases					     239
		   Rennet/Chymosin						     241
		   Other Proteases						     243
		Polymerases							     245
		Nucleases							     248
		   DNases							     249
		   Other Nucleases						     251
		Lipases								     254
		Other Enzymes							     258

	VI.	Industry Structure						     262
		General								     262
		Market Share							     266
		   Novozymes							     267
		   Danisco							     267
		   Roche							     268
		   Allergan							     269
		   Genzyme							     269
		   Other							     270
		Competitive Strategies						     270
		   Research & Development					     272
		   Cooperative Agreements					     274
		   Acquisitions & Divestitures					     279
		Manufacturing							     282
		Marketing & Distribution					     284
		Company Profiles						     286
		   AB Enzymes, see Associated British Foods
		   Abbott Laboratories						     287
		   Agilent Technologies Incorporated				     288
		   Alere Incorporated						     291
		   Allergan Incorporated					     293
		   Amano Enzyme Incorporated					     294
		   Associated British Foods plc					     296
		   Axcan Intermediate Holdings Incorporated			     299
		   BASF SE							     301
		   British Biocell International, see Alere
		   Cargill Incorporated						     303
		   Chr. Hansen A/S						     305
		   Codexis Incorporated						     307
		   Danisco A/S							     310
		   DFB Pharmaceuticals Incorporated				     317
		   Dyadic International Incorporated				     319
		   Frutarom Limited						     322
		   Genencor, see Danisco
		   Genentech, see Roche Holding
		   Genzyme Corporation						     323
		   Healthpoint, see DFB Pharmaceuticals
		   Iogen Corporation						     326
		   Ipsen							     329
		   Johnson & Johnson						     330
		   Life Technologies Corporation				     333
		   Lonza Group Limited						     336
		   Microbix Biosystems Incorporated				     337
		   MP Biomedicals LLC						     338
		   National Enzyme Company					     340
		   New England BioLabs Incorporated				     342
		   Novozymes A/S						     344
		   Promega Corporation						     350
		   Roche Holding Limited					     353
		   Royal DSM NV							     358
		   Shire plc							     366
		   Solstice Neurosciences Incorporated				     369
		   Solvay SA							     370
		   Specialty Enzymes & Biotechnologies Company			     371
		   Verenium Corporation						     374
		Other Companies Mentioned in Study				     379



				      LIST OF TABLES

    TABLE NUMBER								    PAGE


		SECTION I -- Executive Summary
		   Summary Table						       3

		SECTION II -- Market Environment
	1	Population & Households						       8
	2	Macroeconomic Indicators					      12
	3	Personal Consumption Expenditures				      14
	4	Manufacturers’ Shipments					      17
	5	Food & Beverage Shipments					      21
	6	Agricultural Indicators						      24
	7	Major Crop Production						      26
	8	Livestock & Poultry Population					      27
	9	National Health Expenditures					      30
	10	Petroleum Industry Indicators					      33
	11	Enzyme Market, 1999-2009					      36
	12	Selected Enzyme Pricing						      39
	13	Enzyme Production & Foreign Trade				      46

		SECTION IV -- Markets
	1	Enzyme Demand by Market						      66
	2	Pharmaceutical Shipments					      69
	3	Pharmaceutical Enzyme Demand by Market, Status & Product	      73
	4	Enzyme Replacement Therapy Demand by Pharmaceutical
		   & Product							      77
	5	Neuromodulator Enzyme Demand					      79
	6	Digestive Enzyme Demand by Application & Product		      83
	7	Cardiovascular Thrombolytic Enzyme Demand by Application, 
		   Type & Product						      90
	8	Other Pharmaceutical Enzyme Demand by Type & Product		      91
	9	Biofuel Supply & Demand						      99
	10	Biofuel Enzyme Demand by Application & Product			     101
	11	Food & Beverage Enzyme Demand by Application & Product		     109
	12	Corn Sweetener Supply & Demand					     111
	13	Corn Sweetener Enzyme Demand by Application & Product		     114
	14	Dairy Product Shipments						     117
	15	Dairy Enzyme Demand by Application & Product			     119
	16	Cheese Enzyme Demand						     122
	17	Other Dairy Product Enzyme Demand				     124
	18	Bakery Product Shipments					     126
	19	Bakery Product Enzyme Demand					     130
	20	Beverage Shipments						     133
	21	Beverage Enzyme Demand						     134
	22	Other Food & Beverage Enzyme Demand				     142
	23	Research Expenditures						     145
	24	Research & Biotechnology Enzyme Demand by Type
		   & Product							     147
	25	DNA Amplification & Sequencing Enzyme Demand			     150
	26	Other Research & Biotechnology Enzyme Demand			     152
	27	Cleaning Product Supply & Demand				     155
	28	Cleaning Product Enzyme Demand by Application & Product		     157
	29	Laundry Detergent Enzyme Demand					     160
	30	Dishwashing & Other Cleaning Product Enzyme Demand		     162
	31	In Vitro Diagnostic Product Shipments				     165
	32	Diagnostic Enzyme Demand					     169
	33	Animal Feed Shipments						     174
	34	Animal Feed Enzyme Demand by Application & Product		     177
	35	Other Enzyme Demand by Market & Product				     182
	36	Biocatalyst Enzyme Demand					     186
	37	Cosmetic & Toiletry Enzyme Demand				     189
	38	Textile & Leather Enzyme Demand by Application
		   & Product							     191
	39	Pulp & Paper Enzyme Demand					     200
	40	All Other Enzyme Markets					     201

		SECTION V -- Products
	1	Enzyme Demand by Product					     208
	2	Carbohydrase Demand by Product & Market				     212
	3	Alpha Amylase Demand						     217
	4	Glucoamylase Demand						     219
	5	Recombinant Human Glycosidase Demand				     221
	6	Cellulase Demand						     224
	7	Glucose Isomerase Demand					     226
	8	Lactase Demand							     228
	9	Pectinase Demand						     231
	10	Other Carbohydrase Demand					     233
	11	Protease Demand by Product & Market				     235
	12	Microbial Protease Demand					     239
	13	Fibrinolytic Protease Demand					     241
	14	Rennet/Chymosin Demand						     243
	15	Other Protease Demand						     245
	16	Polymerase Demand						     247
	17	Nuclease Demand by Product & Market				     249
	18	DNase Demand							     251
	19	Other Nuclease Demand						     254
	20	Lipase Demand							     257
	21	Other Enzyme Demand						     261

		SECTION VI -- Industry Structure
	1	Enzyme Sales by Company, 2009					     264
	2	Selected Cooperative Agreements					     277
	3	Selected Acquisitions & Divestitures				     281

		      LIST OF CHARTS

    CHART NUMBER								    PAGE

		SECTION II -- Market Environment
	1	Enzyme Market, 1999-2009					      37
	2	US Enzyme Imports by Source, 2009				      48
	3	US Enzyme Exports by Destination, 2009				      50

		SECTION IV -- Markets
	1	Enzyme Demand by Market, 2009					      67

		SECTION V -- Products
	1	Enzyme Demand by Product, 2009					     209

		SECTION VI -- Industry Structure
	1	US Enzyme Market Share by Company, 2009				     266