TABLE OF CONTENTS
SECTION PAGE
INTRODUCTION ix
I. EXECUTIVE SUMMARY 1
II. MARKET ENVIRONMENT 4
General 4
Macroeconomic Overview 5
Demographic Patterns 8
Health Care Trends 11
Medical Providers 12
Patient Activity 16
Surgical Procedures 17
Dental Procedures 20
National Health Expenditures 22
Regulatory Trends 25
Competitive Products Overview 27
Historical Market Trends 31
Pricing Trends 33
Foreign Trade 37
World Medical & Dental Adhesives & Sealants Demand 39
III. PRODUCTS 43
General 43
Synthetic Polymer Adhesives & Sealants 45
Acrylic 48
Cyanoacrylate 51
Types 53
Producers & Products 53
Silicone 57
Polyethylene Glycol 59
Other Synthetic 61
Natural-Based Adhesives & Sealants 63
Plasma & Protein 65
Collagen 68
Fibrin 71
Albumin 75
Other Plasma & Protein-Based Adhesives & Sealants 77
Other Natural Adhesives & Sealants 80
IV. APPLICATIONS 83
General 83
Medical Applications 86
Internal Medical 87
Cardiovascular 91
Bone 94
Demand by Product 95
Demand by Procedure 98
Cranial 101
Pulmonary 103
Abdominal 105
Other Internal 107
External Medical 109
Tissue Bonding 111
Prosthesis Attachment 114
Other External 116
Dental Applications 118
Denture Bonding Agents 120
Pit & Fissure Sealants 123
Restorative Adhesives 125
Orthodontic Bonding Agents 127
Luting Cements 128
Tray Adhesives 131
Dental Surgical Tissue Bonding 132
V. MARKETS 133
General 133
Primary Care 135
Dental Offices 138
Consumer 140
VI. INDUSTRY STRUCTURE 143
General 143
Market Share 145
Baxter International 148
Stryker 148
DENTSPLY International 149
Procter & Gamble 149
King Pharmaceuticals 149
Other Leaders 149
Competitive Strategies 151
Acquisitions & Divestitures 152
Licensing & Related Cooperative Agreements 154
Research & Development 157
Marketing & Distribution 160
Raw Materials & Manufacturing 162
Company Profiles 163
Advanced Medical Solutions Group plc 164
Allergan Incorporated 166
Angiotech Pharmaceuticals Incorporated 167
Baxter International Incorporated 169
Biomet Incorporated 170
Closure Medical Corporation, see Johnson & Johnson
Competitive Technologies Incorporated 172
Confluent Surgical Incorporated, see Tyco International
CryoLife Incorporated 173
CSL Limited 174
Danaher Corporation 175
Den-Mat Corporation 177
DENTSPLY International Incorporated 178
DePuy Incorporated, see Johnson & Johnson
Ethicon Incorporated, see Johnson & Johnson
GC Corporation 180
GlaxoSmithKline plc 183
Haemacure Corporation 184
HemCon Medical Technologies Incorporated 185
Henkel KGaA 187
Heraeus Holding GmbH 188
Ivoclar Vivadent AG 190
Johnson & Johnson 192
Jones Pharma Incorporated, see King Pharmaceutical
Kerr Corporation, see Danaher Corporation
King Pharmaceuticals Incorporated 196
Loctite Engineering Adhesives, see Henkel KGaA
Medlogic Global Limited, see Advanced Medical Solutions
Norian Corporation, see Synthes Incorporated
Ormco Corporation, see Danaher Corporation
Orthovita Incorporated 197
Pharming Group NV 199
Prestige Brands Holdings Incorporated 200
Procter & Gamble Company 201
Protein Polymer Technologies Incorporated 202
Smith & Nephew plc 203
Stryker Corporation 204
Sybron Dental Specialties Incorporated, see Danaher
Syneture, see Tyco International Limited
Synthes Incorporated 206
ThermoGenesis Corporation 207
3M Company 209
Tyco International Limited 211
ZLB Behring LLC, see CSL Limited
Other Companies Mentioned in Study 213
LIST OF TABLES
TABLE NUMBER PAGE
SECTION I -- EXECUTIVE SUMMARY
Summary Table 3
SECTION II -- MARKET ENVIRONMENT
1 Macroeconomic Overview 8
2 Population by Age Group 11
3 Medical Providers 15
4 Patient Activity 17
5 Surgical Procedures by Type 20
6 Dental Patient Activity & Procedures 22
7 National Health Expenditures 25
8 Wound Closures Demand 30
9 Medical & Dental Adhesives & Sealants Market, 1996-2006 32
10 Selected Medical & Dental Adhesives & Sealants Pricing 37
SECTION III -- PRODUCTS
1 Medical & Dental Adhesives & Sealants Demand by Product 44
2 Synthetic Polymer Medical & Dental Adhesives & Sealants
Demand by Product & Application 47
3 Acrylic Medical & Dental Adhesives & Sealants Demand 51
4 Cyanoacrylate Medical & Dental
Adhesives & Sealants Demand 52
5 Silicone Medical & Dental Adhesives Demand 59
6 Polyethylene Glycol Medical Sealants Demand 61
7 Other Synthetic Polymer Medical & Dental
Adhesives & Sealants Demand 63
8 Natural-Based Medical & Dental Adhesives & Sealants
Demand by Product & Application 65
9 Plasma & Protein-Based Medical & Dental
Adhesives & Sealants Demand by Product 67
10 Collagen Medical Sealants Demand 71
11 Fibrin Medical & Dental Sealants Demand by Origin 75
12 Albumin Medical Sealants Demand 77
13 Other Plasma & Protein-Based Medical & Dental
Adhesives & Sealants Demand 79
14 Other Natural Medical & Dental Adhesives & Sealants
Demand by Product 82
SECTION IV -- APPLICATIONS
1 Medical & Dental Adhesives & Sealants Demand
by Application 85
2 Medical Applications for Adhesives & Sealants
by Segment & Product 87
3 Internal Medical Applications for Adhesives & Sealants
by Segment & Product 90
4 Cardiovascular Applications for Adhesives & Sealants 94
5 Bone Applications for Adhesives & Sealants 95
6 Bone Applications for Adhesives & Sealants by Procedure 101
7 Cranial Applications for Adhesives & Sealants 103
8 Pulmonary Applications for Adhesives & Sealants 105
9 Abdominal Applications for Adhesives & Sealants 107
10 Other Internal Medical Applications for Adhesives
& Sealants 109
11 External Medical Applications for Adhesives & Sealants
by Segment & Product 110
12 Tissue Bonding Applications for Adhesives & Sealants 114
13 Prosthesis Applications for Adhesives & Sealants 116
14 Other External Medical Applications for Adhesives
& Sealants 117
15 Dental Applications for Adhesives & Sealants by Segment
& Product 119
16 Denture Bonding Agents Demand 123
17 Pit & Fissure Sealants Demand 125
18 Restorative Adhesives Demand 126
19 Orthodontic Bonding Agents Demand 128
20 Luting Cements Demand 130
21 Tray Adhesives Demand 131
22 Dental Surgical Tissue Bonding Adhesives & Sealants Demand 132
SECTION V -- MARKETS
1 Medical & Dental Adhesives & Sealants Demand by Market 134
2 Primary Care Market for Medical & Dental Adhesives
& Sealants 138
3 Dental Offices Market for Medical & Dental
Adhesives & Sealants 140
4 Consumer Market for Medical & Dental Adhesives & Sealants 142
SECTION VI -- INDUSTRY STRUCTURE
1 US Medical & Dental Adhesives & Sealants Sales
by Company, 2006 146
2 Selected Acquisitions & Divestitures 153
3 Selected Cooperative Agreements 156
4 Research & Development Spending Patterns: Selected
Medical & Dental Adhesives & Sealants Suppliers 160
LIST OF CHARTS
CHART NUMBER PAGE
SECTION II -- MARKET ENVIRONMENT
1 Medical & Dental Adhesives & Sealants Demand
per Capita, 1996-2006 33
2 World Medical & Dental Adhesives & Sealants Demand
by Region, 2006 42
SECTION III -- PRODUCTS
1 Synthetic Polymer Medical & Dental Adhesives & Sealants
Demand by Type, 2006 48
2 Plasma & Protein-Based Medical & Dental
Adhesives & Sealants Demand by Product, 2006 68
SECTION IV -- APPLICATIONS
1 Medical & Dental Adhesives & Sealants Demand
by Application, 1996-2016 85
2 Internal Medical Applications for Adhesives &
Sealants, 2006 91
3 External Medical Applications for Adhesives & Sealants
by Segment, 2006 111
4 Dental Applications for Adhesives & Sealants
by Segment, 2006 120
SECTION V -- MARKETS
1 Medical & Dental Adhesives & Sealants Demand
by Market, 2006 135
SECTION VI -- INDUSTRY STRUCTURE
1 US Medical & Dental Adhesives & Sealants Sales
by Company, 2006 148
