Excipients

As Quoted In InPharm

As drug makers seek to counter intensifying generic competition and rising production costs, they are using excipients to not only carry their active ingredients, but to add value to them.

US demand to rise 3.9% annually through 2015

US demand for excipients will advance 3.9 percent annually to $1.9 billion in 2015, driven by continued growth in US pharmaceutical production and the increasing importance of functional excipients in drug formulation. As pharmaceutical manufacturers seek to offset the impact of intensifying generic competition and increasing production costs, excipients -- once viewed as simple carriers for active ingredients -- are increasingly being called upon to add value to pharmaceutical products. Excipients can be used to extend shelf life and stability, to improve manufacturing efficiency, and to control the release of medicine in alternative dosing formats such as orally disintegrating tablets (ODTs) and inhalants. Nevertheless, growth will lag that of pharmaceutical output as most excipients are commodity substances with limited pricing flexibility.

Fillers, binders, disintegrants applications among best opportunities

One of the most important developments in the excipient industry is the preparation of special excipient blends that provide manufacturers with ready-made combinations of fillers, binders, disintegrants, lubricants and other products, reducing manufacturing time and standardizing materials to be combined with active ingredients. Some of these blends are specially formulated for use in direct compression, a method of tablet formulation that eliminates several processing steps used in wet and dry granulation. The direct compression excipient market is rapidly expanding, especially for polymer products such as microcrystalline cellulose and povidone.

Orally disintegrating tablets (ODT) are one of the fastest growing drug delivery formats. ODT formulations can be taken without water and are designed to dissolve on the tongue, rather than be swallowed. Excipients benefiting from growth in ODTs include superdisintegrants such as crospovidone, croscarmellose or sodium starch glycolate, and bulking agents such as mannitol.

Excipients will also benefit from expanded use of controlled-release formulations. Typically, medicines are given in a specified dose, and repeated several hours or days later. This has produced problematic side effects, and reduces patient compliance with medical regimens. Manufacturers are giving increased attention to methods of providing drugs continuously in a controlled fashion over a prolonged time. Water insoluble polymers are crucial to this process. A range of polymers -- in particular, cellulose ethers -- will benefit from increasing use of controlled- and extended-release formulations.

Study Scope

This study analyzes the $1.5 billion US excipients industry. It presents historical demand data for the years 2000, 2005 and 2010, and forecasts for 2015 and 2020 by product (e.g., polymers, alcohols, minerals, gelatin, sugars) and application (e.g., fillers and diluents, binders, suspension and viscosity agents, coatings, solvents).

The study also considers market environment factors, details industry structure, evaluates company market share and profiles 48 industry players, including Dow Chemical, FMC and International Specialty Products.

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  1. Excipients

    $4,800.00

  2. INTRODUCTION - EXCIPIENTS TO 2015

    $0.00

  3. Methodology & Sources of Information

    $0.00

  4. EXECUTIVE SUMMARY - EXCIPIENTS TO 2015

    $95.00

  5. Overview

    $35.00

  6. EXCIPIENT DEMAND BY TYPE (million dollars) 2005 - 2020

    $60.00

  7. MARKET ENVIRONMENT - EXCIPIENTS TO 2015

    $1,325.00

  8. General

    $35.00

  9. Economic Factors (1 of 3)

    $35.00

  10. Economic Factors (2 of 3)

    $35.00

  11. Economic Factors (3 of 3)

    $35.00

  12. MACROECONOMIC INDICATORS (billion 2005 dollars) 2000 - 2020

    $60.00

  13. Demographic Patterns (1 of 3)

    $35.00

  14. Demographic Patterns (2 of 3)

    $35.00

  15. Demographic Patterns (3 of 3)

    $35.00

  16. POPULATION & HOUSEHOLDS (million persons) 2000 - 2020

    $60.00

  17. Health Care Trends

    $35.00

  18. National Health Expenditures (1 of 2)

    $35.00

  19. National Health Expenditures (2 of 2)

    $35.00

  20. NATIONAL HEALTH EXPENDITURES BY TYPE (billion dollars) 2000 - 2020

    $60.00

  21. NATIONAL HEALTH EXPENDITURES BY SOURCE (billion dollars) 2000 - 2020

    $60.00

  22. Medical Conditions - Chronic (1 of 2)

    $35.00

  23. Medical Conditions - Chronic (2 of 2)

    $35.00

  24. CHRONIC CONDITIONS BY TYPE (million conditions) 2000 - 2020

    $60.00

  25. Medical Conditions - Acute

    $35.00

  26. ACUTE CONDITIONS BY TYPE (million conditions) 2000 - 2020

    $60.00

  27. PHARMACEUTICAL SUPPLY & DEMAND 2000 - 2020

    $60.00

  28. Pharmaceuticals - Therapeutic Class (1 of 2)

    $35.00

  29. Pharmaceuticals - Therapeutic Class (2 of 2)

    $35.00

  30. PHARMACEUTICAL SHIPMENTS BY THERAPEUTIC CLASS (billion dollars) 2000 - 2020

    $60.00

  31. Pharmaceuticals - Dosage Formulations

    $35.00

  32. PHARMACEUTICAL SHIPMENTS BY DOSAGE FORMULATION (billion dollars) 2000 - 2020

    $60.00

  33. Pharmaceuticals - Distribution Classifications

    $35.00

  34. PHARMACEUTICAL SHIPMENTS BY DISTRIBUTION CLASSIFICATION (billion dollars) 2000 - 2020

    $60.00

  35. EXCIPIENT MARKET, 2000 - 2010

    $60.00

  36. Foreign Trade

    $35.00

  37. International Markets

    $35.00

  38. PRODUCTS - EXCIPIENTS TO 2015

    $5,315.00

  39. Overview (1 of 3)

    $35.00

  40. Overview (2 of 3)

    $35.00

  41. Overview (3 of 3)

    $35.00

  42. PHARMACEUTICAL EXCIPIENT DEMAND BY PRODUCT GROUP (million dollars) 2000 - 2020

    $60.00

  43. Polymer Excipients - Overview

    $35.00

  44. POLYMER EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  45. Polymer Excipients - Cellulose Derivatives

    $35.00

  46. CELLULOSE EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  47. Cellulose Excipients - Microcrystalline Cellulose (MCC) (1 of 3)

    $35.00

  48. Cellulose Excipients - Microcrystalline Cellulose (MCC) (2 of 3)

    $35.00

  49. Cellulose Excipients - Microcrystalline Cellulose (MCC) (3 of 3)

    $35.00

  50. MICROCRYSTALLINE CELLULOSE EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  51. Cellulose Excipients - Hydroxypropyl Methylcellulose (HPMC) (1 of 2)

    $35.00

  52. Cellulose Excipients - Hydroxypropyl Methylcellulose (HPMC) (2 of 2)

    $35.00

  53. HYDROXYPROPYL METHYLCELLULOSE EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  54. Cellulose Excipients - Ethyl Cellulose

    $35.00

  55. ETHYL CELLULOSE EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  56. Cellulose Excipients - Methyl Cellulose

    $35.00

  57. METHYL CELLULOSE EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  58. Cellulose Excipients - Carboxymethylcellulose (CMC) (1 of 2)

    $35.00

  59. Cellulose Excipients - Carboxymethylcellulose (CMC) (2 of 2)

    $35.00

  60. CARBOXYMETHYLCELLULOSE EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  61. Cellulose Excipients - Croscarmellose Sodium

    $35.00

  62. CROSCARMELLOSE SODIUM EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  63. Other Cellulose Excipients (1 of 3)

    $35.00

  64. Other Cellulose Excipients (2 of 3)

    $35.00

  65. Other Cellulose Excipients (3 of 3)

    $35.00

  66. OTHER CELLULOSE EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  67. Polymer Excipients - Povidone (1 of 2)

    $35.00

  68. Polymer Excipients - Povidone (2 of 2)

    $35.00

  69. POVIDONE EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  70. Polymer Excipients - Starch Compounds

    $35.00

  71. STARCH EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  72. Starch Excipients - Pregelatinized Starch (1 of 2)

    $35.00

  73. Starch Excipients - Pregelatinized Starch (2 of 2)

    $35.00

  74. PREGELATINIZED STARCH EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  75. Starch Excipients - Sodium Starch Glycolate

    $35.00

  76. SODIUM STARCH EXCIPIENT DEMAND (million dollars) 2000 - 2020

    $60.00

  77. Other Starch Excipients (1 of 3)

    $35.00

  78. Other Starch Excipients (2 of 3)

    $35.00

  79. Other Starch Excipients (3 of 3)

    $35.00

  80. OTHER STARCH EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  81. Polymer Excipients - Polyethylene Glycol (1 of 2)

    $35.00

  82. Polymer Excipients - Polyethylene Glycol (2 of 2)

    $35.00

  83. POLYETHYLENE GLYCOL EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  84. Polymer Excipients - Acrylic Polymers (1 of 3)

    $35.00

  85. Polymer Excipients - Acrylic Polymers (2 of 3)

    $35.00

  86. Polymer Excipients - Acrylic Polymers (3 of 3)

    $35.00

  87. ACRYLIC POLYMER EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  88. OTHER POLYMER EXCIPIENTS BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  89. Other Polymer Excipients - Natural Gums from Seaweeds (1 of 2)

    $35.00

  90. Other Polymer Excipients - Natural Gums from Seaweeds (2 of 2)

    $35.00

  91. Other Polymer Excipients - Other Plant-Based Natural Gums (1 of 3)

    $35.00

  92. Other Polymer Excipients - Other Plant-Based Natural Gums (2 of 3)

    $35.00

  93. Other Polymer Excipients - Other Plant-Based Natural Gums (3 of 3)

    $35.00

  94. Other Polymer Excipients - Synthetic Polymers

    $35.00

  95. ALCOHOL EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  96. Alcohol Excipients - Glycerin

    $35.00

  97. GLYCERIN EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  98. Alcohol Excipients - Propylene Glycol

    $35.00

  99. PROPYLENE GLYCOL EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  100. Alcohol Excipients - Sorbitol

    $35.00

  101. SORBITOL EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  102. Other Alcohol Excipients - Overview

    $35.00

  103. OTHER ALCOHOL EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  104. OTHER ALCOHOL EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  105. Other Alcohol Excipients - Mannitol

    $35.00

  106. Other Alcohol Excipients - Other Polyols & All Other Alcohols (1 of 3)

    $35.00

  107. Other Alcohol Excipients - Other Polyols & All Other Alcohols (2 of 3)

    $35.00

  108. Other Alcohol Excipients - Other Polyols & All Other Alcohols (3 of 3)

    $35.00

  109. MINERAL EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  110. Mineral Excipients - Calcium Phosphate (1 of 2)

    $35.00

  111. Mineral Excipients - Calcium Phosphate (2 of 2)

    $35.00

  112. CALCIUM PHOSPHATE EXCIPIENT DEMAND (million dollars) 2000 - 2020

    $60.00

  113. Mineral Excipients - Calcium Carbonate

    $35.00

  114. CALCIUM CARBONATE EXCIPIENT DEMAND (million dollars) 2000 - 2020

    $60.00

  115. Mineral Excipients - Mineral Hydrocarbons (1 of 2)

    $35.00

  116. Mineral Excipients - Mineral Hydrocarbons (2 of 2)

    $35.00

  117. MINERAL HYDROCARBON EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  118. Mineral Excipients - Clay (1 of 2)

    $35.00

  119. Mineral Excipients - Clay (2 of 2)

    $35.00

  120. CLAY EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  121. Mineral Excipients - Silicon Dioxide (1 of 2)

    $35.00

  122. Mineral Excipients - Silicon Dioxide (2 of 2)

    $35.00

  123. SILICON DIOXIDE EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  124. Mineral Excipients - Titanium Dioxide

    $35.00

  125. TITANIUM DIOXIDE EXCIPIENT DEMAND (million dollars) 2000 - 2020

    $60.00

  126. Other Mineral Excipients (1 of 2)

    $35.00

  127. Other Mineral Excipients (2 of 2)

    $35.00

  128. OTHER MINERAL EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  129. Gelatin Excipients (1 of 3)

    $35.00

  130. Gelatin Excipients (2 of 3)

    $35.00

  131. Gelatin Excipients (3 of 3)

    $35.00

  132. GELATIN EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  133. SUGAR EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  134. Sugar Excipients - Lactose (1 of 2)

    $35.00

  135. Sugar Excipients - Lactose (2 of 2)

    $35.00

  136. LACTOSE EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  137. Sugar Excipients - Sucrose

    $35.00

  138. SUCROSE EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  139. Other Sugar Excipients (1 of 2)

    $35.00

  140. Other Sugar Excipients (2 of 2)

    $35.00

  141. OTHER SUGAR EXCIPIENT DEMAND (million dollars) 2000 - 2020

    $60.00

  142. OTHER PHARMACEUTICAL EXCIPIENTS DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  143. OTHER PHARMACEUTICAL EXCIPIENTS DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  144. Other Pharmaceutical Excipients - Dyes & Pigments

    $35.00

  145. Other Pharmaceutical Excipients - Flavors

    $35.00

  146. Other Pharmaceutical Excipients - Surfactants (1 of 3)

    $35.00

  147. Other Pharmaceutical Excipients - Surfactants (2 of 3)

    $35.00

  148. Other Pharmaceutical Excipients - Surfactants (3 of 3)

    $35.00

  149. Other Pharmaceutical Excipients - Acidulants (1 of 2)

    $35.00

  150. Other Pharmaceutical Excipients - Acidulants (2 of 2)

    $35.00

  151. Other Pharmaceutical Excipients - Antioxidants (1 of 2)

    $35.00

  152. Other Pharmaceutical Excipients - Antioxidants (2 of 2)

    $35.00

  153. Other Pharmaceutical Excipients - Stearate Compounds (1 of 4)

    $35.00

  154. Other Pharmaceutical Excipients - Stearate Compounds (2 of 4)

    $35.00

  155. Other Pharmaceutical Excipients - Stearate Compounds (3 of 4)

    $35.00

  156. Other Pharmaceutical Excipients - Stearate Compounds (4 of 4)

    $35.00

  157. All Other Pharmaceutical Excipients - Electrolytes & Related

    $35.00

  158. All Other Pharmaceutical Excipients - Chemical Plasticizers

    $35.00

  159. All Other Pharmaceutical Excipients - High Intensity Sweeteners

    $35.00

  160. All Other Pharmaceutical Excipients - Natural Fats, Oils & Waxes (1 of 3)

    $35.00

  161. All Other Pharmaceutical Excipients - Natural Fats, Oils & Waxes (2 of 3)

    $35.00

  162. All Other Pharmaceutical Excipients - Natural Fats, Oils & Waxes (3 of 3)

    $35.00

  163. APPLICATIONS - EXCIPIENTS TO 2015

    $1,165.00

  164. Overview

    $35.00

  165. PHARMACEUTICAL EXCIPIENT DEMAND BY APPLICATION (million dollars) 2000 - 2020

    $60.00

  166. Fillers & Diluents - Excipient Demand

    $35.00

  167. FILLER & DILUENT EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  168. Binders - Excipient Demand

    $35.00

  169. BINDER EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  170. Suspension & Viscosity Agents - Excipient Demand

    $35.00

  171. SUSPENSION & VISCOSITY EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  172. Coatings - Excipient Demand

    $35.00

  173. COATING EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  174. Solvents - Excipient Demand

    $35.00

  175. SOLVENT EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  176. Flavoring Agents - Excipient Demand

    $35.00

  177. FLAVORING AGENT EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  178. Capsules - Excipient Demand (1 of 2)

    $35.00

  179. Capsules - Excipient Demand (2 of 2)

    $35.00

  180. CAPSULE EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  181. DISINTEGRANT EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  182. COLORANT EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  183. Lubricants & Glidants - Excipient Demand

    $35.00

  184. LUBRICANT & GLIDANT EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  185. PRESERVATIVE EXCIPIENT DEMAND BY TYPE (million dollars) 2000 - 2020

    $60.00

  186. Other Applications - Excipient Demand

    $35.00

  187. OTHER APPLICATIONS FOR EXCIPIENTS BY TYPE 2000 - 2020

    $60.00

  188. INDUSTRY STRUCTURE - EXCIPIENTS TO 2015

    $520.00

  189. General

    $35.00

  190. US EXCIPIENT SALES BY COMPANY, 2010 (million dollars)

    $60.00

  191. Market Share

    $35.00

  192. US EXCIPIENT MARKET SHARE BY COMPANY, 2010 (percent)

    $60.00

  193. Competitive Strategies

    $35.00

  194. Selected Mergers & Acquisitions

    $35.00

  195. SELECTED ACQUISITIONS & DIVESTITURES

    $60.00

  196. Selected Licensing & Related Agreements

    $35.00

  197. SELECTED COOPERATIVE AGREEMENTS

    $60.00

  198. Marketing & Distribution

    $35.00

  199. Research & Development

    $35.00

  200. Manufacturing

    $35.00

  201. COMPANY PROFILES - EXCIPIENTS TO 2015

    $2,205.00

  202. Company Profiles Methodology

    $35.00

  203. Akzo Nobel (Cellulosic Specialties)

    $35.00

  204. Archer-Daniels-Midland Company

    $35.00

  205. Ashland Incorporated

    $35.00

  206. Associated British Foods (SPI Pharma) (ABITEC) (1 of 2)

    $35.00

  207. Associated British Foods (SPI Pharma) (ABITEC) (2 of 2)

    $35.00

  208. AVANTOR Performance Materials (Mallinckrodt Baker)

    $35.00

  209. BASF SE (Cognis) (1 of 3)

    $35.00

  210. BASF SE (Cognis) (2 of 3)

    $35.00

  211. BASF SE (Cognis) (3 of 3)

    $35.00

  212. Berwind Corporation (Colorcon) (1 of 2)

    $35.00

  213. Berwind Corporation (Colorcon) (2 of 2)

    $35.00

  214. Cabot Corporation

    $35.00

  215. Cargill Incorporated (1 of 2)

    $35.00

  216. Cargill Incorporated (2 of 2)

    $35.00

  217. Celanese Corporation (Nutrinova)

    $35.00

  218. Corn Products International (National Starch)

    $35.00

  219. Covidien plc

    $35.00

  220. Croda International

    $35.00

  221. Danisco A/S

    $35.00

  222. Dow Chemical Company (1 of 4)

    $35.00

  223. Dow Chemical Company (2 of 4)

    $35.00

  224. Dow Chemical Company (3 of 4)

    $35.00

  225. Dow Chemical Company (4 of 4)

    $35.00

  226. Eastman Chemical Company

    $35.00

  227. Evonik Industries

    $35.00

  228. Ferro Corporation

    $35.00

  229. FibroGen Incorporated

    $35.00

  230. Flavorx Incorporated

    $35.00

  231. FMC Corporation (1 of 2)

    $35.00

  232. FMC Corporation (2 of 2)

    $35.00

  233. GELITA AG

    $35.00

  234. Generichem Corporation

    $35.00

  235. Huber (JM) Corporation (CP Kelco) (1 of 2)

    $35.00

  236. Huber (JM) Corporation (CP Kelco) (2 of 2)

    $35.00

  237. Huntsman Corporation

    $35.00

  238. Innophos Incorporated

    $35.00

  239. International Specialty Products

    $35.00

  240. Kraft Foods

    $35.00

  241. Kuraray Company

    $35.00

  242. Ligand Pharmaceuticals (CyDex)

    $35.00

  243. Lubrizol Corporation

    $35.00

  244. LyondellBasell Industries (Bayport)

    $35.00

  245. Merck KGaA (EMD Chemicals)

    $35.00

  246. Mutchler Incorporated

    $35.00

  247. Nitta Gelatin

    $35.00

  248. NutraSweet Company

    $35.00

  249. Procter & Gamble Company (P&G Chemicals)

    $35.00

  250. Rettenmaier (J.) & Söhne GmbH & Company (JRS Pharma)

    $35.00

  251. Roquette Frères (1 of 2)

    $35.00

  252. Roquette Frères (2 of 2)

    $35.00

  253. Royal Dutch Shell

    $35.00

  254. Sasol Limited

    $35.00

  255. Shin-Etsu Chemical Company

    $35.00

  256. Solvay SA

    $35.00

  257. Stepan Company

    $35.00

  258. Tate & Lyle

    $35.00

  259. Tessenderlo Group (PB Leiner) (PB Gelatins)

    $35.00

  260. USG Corporation

    $35.00

  261. Wacker Chemie (1 of 2)

    $35.00

  262. Wacker Chemie (2 of 2)

    $35.00

  263. Other Companies Involved in the US Excipients Industry (1 of 2)

    $35.00

  264. Other Companies Involved in the US Excipients Industry (2 of 2)

    $35.00

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