Excipients

As Quoted In InPharm

As drug makers seek to counter intensifying generic competition and rising production costs, they are using excipients to not only carry their active ingredients, but to add value to them.

US demand to rise 3.9% annually through 2015

US demand for excipients will advance 3.9 percent annually to $1.9 billion in 2015, driven by continued growth in US pharmaceutical production and the increasing importance of functional excipients in drug formulation. As pharmaceutical manufacturers seek to offset the impact of intensifying generic competition and increasing production costs, excipients -- once viewed as simple carriers for active ingredients -- are increasingly being called upon to add value to pharmaceutical products. Excipients can be used to extend shelf life and stability, to improve manufacturing efficiency, and to control the release of medicine in alternative dosing formats such as orally disintegrating tablets (ODTs) and inhalants. Nevertheless, growth will lag that of pharmaceutical output as most excipients are commodity substances with limited pricing flexibility.

Fillers, binders, disintegrants applications among best opportunities

One of the most important developments in the excipient industry is the preparation of special excipient blends that provide manufacturers with ready-made combinations of fillers, binders, disintegrants, lubricants and other products, reducing manufacturing time and standardizing materials to be combined with active ingredients. Some of these blends are specially formulated for use in direct compression, a method of tablet formulation that eliminates several processing steps used in wet and dry granulation. The direct compression excipient market is rapidly expanding, especially for polymer products such as microcrystalline cellulose and povidone.

Orally disintegrating tablets (ODT) are one of the fastest growing drug delivery formats. ODT formulations can be taken without water and are designed to dissolve on the tongue, rather than be swallowed. Excipients benefiting from growth in ODTs include superdisintegrants such as crospovidone, croscarmellose or sodium starch glycolate, and bulking agents such as mannitol.

Excipients will also benefit from expanded use of controlled-release formulations. Typically, medicines are given in a specified dose, and repeated several hours or days later. This has produced problematic side effects, and reduces patient compliance with medical regimens. Manufacturers are giving increased attention to methods of providing drugs continuously in a controlled fashion over a prolonged time. Water insoluble polymers are crucial to this process. A range of polymers -- in particular, cellulose ethers -- will benefit from increasing use of controlled- and extended-release formulations.

Study Scope

This study analyzes the $1.5 billion US excipients industry. It presents historical demand data for the years 2000, 2005 and 2010, and forecasts for 2015 and 2020 by product (e.g., polymers, alcohols, minerals, gelatin, sugars) and application (e.g., fillers and diluents, binders, suspension and viscosity agents, coatings, solvents).

The study also considers market environment factors, details industry structure, evaluates company market share and profiles 48 industry players, including Dow Chemical, FMC and International Specialty Products.

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Purchase Excipients by the Section

  1. Excipients

    $4,800.00

    1. 1 INTRODUCTION

      $106.00

    2. 2 EXECUTIVE SUMMARY

      $141.00

      1. Table | EXCIPIENT DEMAND BY TYPE (million dollars)

    3. 3 MARKET ENVIRONMENT

      $1,342.00

      1. 3.1 General

        $82.00

      2. 3.2 Economic Factors

        $201.00

        1. Table | MACROECONOMIC INDICATORS (billion 2005 dollars)

      3. 3.3 Demographic Patterns

        $207.00

        1. Table | POPULATION & HOUSEHOLDS (million persons)

      4. 3.4 Health Care Trends

        $419.00

        1. 3.4.1 National Health Expenditures

          $159.00

          1. Table | NATIONAL HEALTH EXPENDITURES (billion dollars)

        2. 3.4.2 Medical Conditions

          $220.00

          1. Table | CHRONIC CONDITIONS BY TYPE (million conditions)

          2. Table | ACUTE CONDITIONS BY TYPE (million conditions)

      5. 3.5 Pharmaceuticals

        $333.00

        1. Table | PHARMACEUTICAL SUPPLY & DEMAND

        2. 3.5.1 Therapeutic Class

          $114.00

          1. Table | PHARMACEUTICAL SHIPMENTS BY THERAPEUTIC CLASS (billion dollars)

        3. 3.5.2 Dosage Formulations

          $91.00

          1. Table | PHARMACEUTICAL SHIPMENTS BY DOSAGE FORMULATION (billion dollars)

        4. 3.5.3 Distribution Classifications

          $86.00

          1. Table | PHARMACEUTICAL SHIPMENTS BY DISTRIBUTION CLASSIFICATION (billion dollars)

      6. 3.6 Historical Market Trends

        $82.00

        1. Table | EXCIPIENT MARKET, 2000-2010

      7. 3.7 Foreign Trade

        $82.00

      8. 3.8 International Markets

        $82.00

    4. 4 PRODUCTS

      $4,830.00

      1. 4.1 General

        $206.00

        1. Table | PHARMACEUTICAL EXCIPIENT DEMAND BY PRODUCT GROUP (million dollars)

      2. 4.2 Polymers

        $2,097.00

        1. Table | POLYMER EXCIPIENT DEMAND BY TYPE (million dollars)

        2. 4.2.1 Cellulose Derivatives

          $816.00

          1. Table | CELLULOSE EXCIPIENT DEMAND BY TYPE (million dollars)

          2. Table | MICROCRYSTALLINE CELLULOSE EXCIPIENT DEMAND BY APPLICATION (million dollars)

          3. Table | HYDROXYPROPYL METHYLCELLULOSE EXCIPIENT DEMAND BY APPLICATION (million dollars)

          4. Table | ETHYL CELLULOSE EXCIPIENT DEMAND BY APPLICATION (million dollars)

          5. Table | METHYL CELLULOSE EXCIPIENT DEMAND BY APPLICATION (million dollars)

          6. Table | CARBOXYMETHYLCELLULOSE EXCIPIENT DEMAND BY APPLICATION (million dollars)

          7. Table | CROSCARMELLOSE SODIUM EXCIPIENT DEMAND BY APPLICATION (million dollars)

          8. Table | OTHER CELLULOSE EXCIPIENT DEMAND BY APPLICATION (million dollars)

        3. 4.2.2 Povidone

          $114.00

          1. Table | POVIDONE EXCIPIENT DEMAND BY APPLICATION (million dollars)

        4. 4.2.3 Starch Compounds

          $440.00

          1. Table | STARCH EXCIPIENT DEMAND BY TYPE (million dollars)

          2. Table | PREGELATINIZED STARCH EXCIPIENT DEMAND BY APPLICATION (million dollars)

          3. Table | SODIUM STARCH EXCIPIENT DEMAND (million dollars)

          4. Table | OTHER STARCH EXCIPIENT DEMAND BY APPLICATION (million dollars)

        5. 4.2.4 Polyethylene Glycol

          $131.00

          1. Table | POLYETHYLENE GLYCOL EXCIPIENT DEMAND BY APPLICATION (million dollars)

        6. 4.2.5 Acrylic Polymers

          $165.00

          1. Table | ACRYLIC POLYMER EXCIPIENT DEMAND BY APPLICATION (million dollars)

        7. 4.2.6 Other Polymers

          $380.00

          1. Table | OTHER POLYMER EXCIPIENTS BY APPLICATION (million dollars)

      3. 4.3 Alcohols

        $601.00

        1. Table | ALCOHOL EXCIPIENT DEMAND BY TYPE (million dollars)

        2. 4.3.1 Glycerin

          $89.00

          1. Table | GLYCERIN EXCIPIENT DEMAND BY APPLICATION (million dollars)

        3. 4.3.2 Propylene Glycol

          $82.00

          1. Table | PROPYLENE GLYCOL EXCIPIENT DEMAND BY APPLICATION (million dollars)

        4. 4.3.3 Sorbitol

          $82.00

          1. Table | SORBITOL EXCIPIENT DEMAND BY APPLICATION (million dollars)

        5. 4.3.4 Other Alcohols

          $347.00

          1. Table | OTHER ALCOHOL EXCIPIENT DEMAND BY TYPE & APPLICATION (million dollars)

      4. 4.4 Minerals

        $725.00

        1. Table | MINERAL EXCIPIENT DEMAND BY TYPE (million dollars)

        2. 4.4.1 Calcium Phosphate

          $95.00

          1. Table | CALCIUM PHOSPHATE EXCIPIENT DEMAND (million dollars)

        3. 4.4.2 Calcium Carbonate

          $82.00

          1. Table | CALCIUM CARBONATE EXCIPIENT DEMAND (million dollars)

        4. 4.4.3 Mineral Hydrocarbons

          $143.00

          1. Table | MINERAL HYDROCARBON EXCIPIENT DEMAND BY APPLICATION (million dollars)

        5. 4.4.4 Clay

          $94.00

          1. Table | CLAY EXCIPIENT DEMAND BY APPLICATION (million dollars)

        6. 4.4.5 Silicon Dioxide

          $82.00

          1. Table | SILICON DIOXIDE EXCIPIENT DEMAND BY APPLICATION (million dollars)

        7. 4.4.6 Titanium Dioxide

          $82.00

          1. Table | TITANIUM DIOXIDE EXCIPIENT DEMAND (million dollars)

        8. 4.4.7 Other Minerals

          $148.00

          1. Table | OTHER MINERAL EXCIPIENT DEMAND BY APPLICATION (million dollars)

      5. 4.5 Gelatin

        $204.00

        1. Table | GELATIN EXCIPIENT DEMAND BY APPLICATION (million dollars)

      6. 4.6 Sugars

        $378.00

        1. Table | SUGAR EXCIPIENT DEMAND BY TYPE (million dollars)

        2. 4.6.1 Lactose

          $125.00

          1. Table | LACTOSE EXCIPIENT DEMAND BY APPLICATION (million dollars)

        3. 4.6.2 Sucrose

          $88.00

          1. Table | SUCROSE EXCIPIENT DEMAND BY APPLICATION (million dollars)

        4. 4.6.3 Other Sugar Excipients

          $134.00

          1. Table | OTHER SUGAR EXCIPIENT DEMAND (million dollars)

      7. 4.7 Other Pharmaceutical Excipients

        $1,075.00

        1. Table | OTHER PHARMACEUTICAL EXCIPIENTS DEMAND BY TYPE & APPLICATION (million dollars)

        2. 4.7.1 Dyes & Pigments

          $82.00

        3. 4.7.2 Flavors

          $82.00

        4. 4.7.3 Surfactants

          $150.00

        5. 4.7.4 Acidulants

          $94.00

        6. 4.7.5 Antioxidants

          $82.00

        7. 4.7.6 Stearate Compounds

          $233.00

        8. 4.7.7 All Other Compounds

          $329.00

    5. 5 APPLICATIONS

      $805.00

      1. 5.1 General

        $82.00

        1. Table | PHARMACEUTICAL EXCIPIENT DEMAND BY APPLICATION (million dollars)

      2. 5.2 Fillers & Diluents

        $82.00

        1. Table | FILLER & DILUENT EXCIPIENT DEMAND BY TYPE (million dollars)

      3. 5.3 Binders

        $91.00

        1. Table | BINDER EXCIPIENT DEMAND BY TYPE (million dollars)

      4. 5.4 Suspension & Viscosity Agents

        $82.00

        1. Table | SUSPENSION & VISCOSITY EXCIPIENT DEMAND BY TYPE (million dollars)

      5. 5.5 Coatings

        $82.00

        1. Table | COATING EXCIPIENT DEMAND BY TYPE (million dollars)

      6. 5.6 Solvents

        $82.00

        1. Table | SOLVENT EXCIPIENT DEMAND BY TYPE (million dollars)

      7. 5.7 Flavoring Agents

        $82.00

        1. Table | FLAVORING AGENT EXCIPIENT DEMAND BY TYPE (million dollars)

      8. 5.8 Capsules

        $127.00

        1. Table | CAPSULE EXCIPIENT DEMAND BY TYPE (million dollars)

      9. 5.9 Disintegrants

        $82.00

        1. Table | DISINTEGRANT EXCIPIENT DEMAND BY TYPE (million dollars)

      10. 5.10 Colorants

        $82.00

        1. Table | COLORANT EXCIPIENT DEMAND BY TYPE (million dollars)

      11. 5.11 Lubricants & Glidants

        $82.00

        1. Table | LUBRICANT & GLIDANT EXCIPIENT DEMAND BY TYPE (million dollars)

      12. 5.12 Preservatives

        $82.00

        1. Table | PRESERVATIVE EXCIPIENT DEMAND BY TYPE (million dollars)

      13. 5.13 Other Applications

        $82.00

        1. Table | OTHER APPLICATIONS FOR EXCIPIENTS BY TYPE

    6. 6 INDUSTRY STRUCTURE

      $4,830.00

      1. 6.1 General

        $88.00

        1. Table | US EXCIPIENT SALES BY COMPANY, 2010 (million dollars)

      2. 6.2 Market Share

        $82.00

      3. 6.3 Competitive Strategies

        $82.00

      4. 6.4 Selected Mergers & Acquisitions

        $106.00

        1. Table | SELECTED ACQUISITIONS & DIVESTITURES

      5. 6.5 Selected Licensing & Related Agreements

        $95.00

        1. Table | SELECTED COOPERATIVE AGREEMENTS

      6. 6.6 Marketing & Distribution

        $82.00

      7. 6.7 Research & Development

        $82.00

      8. 6.8 Manufacturing

        $82.00

      9. 6.9 Company Profiles

        $4,830.00

        1. 6.9.1 Akzo Nobel NV

          $84.00

        2. 6.9.2 Archer-Daniels-Midland Company

          $98.00

        3. 6.9.3 Ashland Incorporated

          $145.00

        4. 6.9.4 Associated British Foods plc

          $189.00

        5. 6.9.5 AVANTOR Performance Materials

          $116.00

        6. 6.9.6 BASF SE

          $304.00

        7. 6.9.7 Berwind Corporation

          $184.00

        8. 6.9.8 Cabot Corporation

          $82.00

        9. 6.9.9 Cargill Incorporated

          $213.00

        10. 6.9.10 Celanese Corporation

          $82.00

        11. 6.9.11 Corn Products International Incorporated

          $82.00

        12. 6.9.12 Covidien plc

          $82.00

        13. 6.9.13 Croda International plc

          $109.00

        14. 6.9.14 Danisco A/S

          $148.00

        15. 6.9.15 Dow Chemical Company

          $352.00

        16. 6.9.16 Eastman Chemical Company

          $110.00

        17. 6.9.17 Evonik Industries AG

          $137.00

        18. 6.9.18 Ferro Corporation

          $82.00

        19. 6.9.19 FibroGen Incorporated

          $82.00

        20. 6.9.20 Flavorx Incorporated

          $82.00

        21. 6.9.21 FMC Corporation

          $164.00

        22. 6.9.22 GELITA AG

          $82.00

        23. 6.9.23 Generichem Corporation

          $82.00

        24. 6.9.24 Huber (JM) Corporation

          $168.00

        25. 6.9.25 Huntsman Corporation

          $82.00

        26. 6.9.26 Innophos Incorporated

          $82.00

        27. 6.9.27 International Specialty Products Incorporated

          $151.00

        28. 6.9.28 Kraft Foods Incorporated

          $82.00

        29. 6.9.29 Kuraray Company Limited

          $82.00

        30. 6.9.30 Ligand Pharmaceuticals Incorporated

          $82.00

        31. 6.9.31 Lubrizol Corporation

          $100.00

        32. 6.9.32 LyondellBasell Industries NV

          $82.00

        33. 6.9.33 Merck KGaA

          $82.00

        34. 6.9.34 Mutchler Incorporated

          $82.00

        35. 6.9.35 Nitta Gelatin Incorporated

          $82.00

        36. 6.9.36 NutraSweet Company

          $82.00

        37. 6.9.37 Procter & Gamble Company

          $82.00

        38. 6.9.38 Rettenmaier (J.) & Söhne GmbH & Company KG

          $128.00

        39. 6.9.39 Roquette Frères SA

          $202.00

        40. 6.9.40 Royal Dutch Shell plc

          $82.00

        41. 6.9.41 Sasol Limited

          $86.00

        42. 6.9.42 Shin-Etsu Chemical Company Limited

          $105.00

        43. 6.9.43 Solvay SA

          $99.00

        44. 6.9.44 Stepan Company

          $82.00

        45. 6.9.45 Tate & Lyle plc

          $149.00

        46. 6.9.46 Tessenderlo Group NV

          $82.00

        47. 6.9.47 USG Corporation

          $82.00

        48. 6.9.48 Wacker Chemie AG

          $181.00

      10. 6.10 Other Companies Involved in the US Excipients Industry

        $89.00

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